NFL Week 4 Previews: Quarterback Duels and London Showdown Highlight Slate

Week 4 features Joe Burrow facing Trevor Lawrence and a London matchup where the Colts' league-worst defense meets the Commanders.

NFL Week 4 features several high-profile quarterback matchups, including Joe Burrow facing Trevor Lawrence and Matthew Stafford challenging Jalen Hurts. The action begins Sunday at 9:30 a.m. ET in London as the Indianapolis Colts (1-2) face the Washington Commanders (1-2). The Colts defense enters the contest allowing a league-high 417.3 total yards per game. Indianapolis quarterback Daniel Jones is currently averaging 6.2 yards per attempt, while Commanders receiver Stefon Diggs seeks to surpass his season high of 55 receiving yards against a defense allowing 30.3 points per game.

In Cincinnati, the 2-1 Bengals host the 2-1 Jacksonville Jaguars at 1 p.m. ET. Trevor Lawrence remains winless in three career starts against the Bengals despite throwing for 733 yards and five touchdowns in those games. Joe Burrow enters the matchup with 28 games of three or more passing touchdowns since 2021, the most in the NFL. The Jaguars offense has scored touchdowns on 8.6% of pass attempts this season, while the Bengals defense currently leads the league in yards allowed after the catch.

The Dallas Cowboys (1-2) visit the 0-3 Houston Texans, who expect the return of wide receiver Nico Collins from a hamstring injury. Cowboys quarterback Dak Prescott holds a 31.2 total QBR in two career starts against Houston, his second-lowest mark against any opponent. Meanwhile, the Philadelphia Eagles (2-1) face the Los Angeles Rams (1-2) seeking their first takeaway of the season. Rams defensive tackle Aaron Donald, who has a 33% pass rush win rate, is monitored daily due to a sore back, while Philadelphia running back Saquon Barkley has been held under 10 fantasy points in three consecutive games.